Flower

Blood thinners can cause high risk bleeding in Chronic Kidney disease patients

by Marshaneil Soumi D’ Rozario | 27 JULY 2018

blood thinners can cause high risk bleeding in chronic kidney disease patients
 Image used for representational purpose only

A recent study of the Clinical Journal of the American society of Nephrology (CJASN) suggests that a few anticoagulants used to treat atrial fibrillation can increase the risk of bleeding in CKD patients. Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people as pills, and various intravenous anticoagulant dosage forms are used in hospitals.

 

Some antiplatelet drugs (eptifibatide, tirofiban) and anticoagulants (enoxaparin, dalteparin, fondaparinux, lepirudin) are excreted by the kidneys. Renal dysfunction causes these drugs to accumulate in the body. Their half-life increases, leading to increased bleeding risk. CKD patients in severe uremic state also have severe platelet dysfunction, resulting in increased bleeding due to thinners.

Dr. Rajasekhara Chakravarthi, Senior Nephrologist, Star Hospitals, said, “CKD patients on dialysis require anticoagulants for adequate dialyser function, so when they are not kept on anticoagulants, clearance of unwanted toxins will be drastically effected. CKD patients rarely develop intracranial bleeding, intraocular haemorrhage, and bleeding in the renal cysts during dialysis due to anticoagulation, so every patient is peculiar and has to be carefully monitored as far as bleeding and coagulation risk is concerned.”

 

The use of new oral anticoagulants, like dabigatran etexilate (oral thrombin inhibitor), rivaroxaban and apixaban (oral factor Xa inhibitors), has been increasing due to a decrease in bleeding episodes when compared to warfarin. Renal excretion for dabigatran etexilate, rivaroxaban and apixaban are 80%, 65% and 20% respectively.  However, these drugs are infrequently used due to their cost and dose reduction in renal failure patients. Additionally, dabigatran etexilate is contradicted in patients with creatinine clearance less than 15ml/ min.


 Disclaimer: Welthi.com does not guarantee any specific results as a result of the procedures mentioned here, and the results may vary from person to person. Read more
Cochlear Implants to Aid Children With Hearing Difficulties - Surgery to help in improving speech and language skills among the young  Hyderabad, 14th October 2018: Hearing is a one of the most important sense that also plays a very crucial role in verbal

Cochlear Implants to Aid Children With Hearing ...

Surgery to help in improving speech and language s...
“Maxi-O Lipi Flow” world’s best device for dry eyes treatment launched in MaxiVision Eye Hospitals

“Maxi-O Lipi Flow” world’s best device for ...

Now freedom from dry eyes is just a step away in H...
Different bodies, one message

Different bodies, one message

Aishwarya Sharma, a fashion activist and founder a...
Pediatric Liver transplant in Gleneagles Global Hospitals

Pediatric Liver transplant in Gleneagles Global ...

The Gleneagles Global Hospitals Hyderabad is delig...
Child Obesity: A burgeoning barrier to healthy living

Child Obesity: A burgeoning barrier to healthy ...

The World Obesity Day is celebrated on 11th Octobe...
Get off your smart gadgets

Get off your smart gadgets

The repetitive motions of texting and typing can l...
Hyderabad Doctors successfully perform Asia's First Transcatheter Tricuspid Valve Replacement procedure

Hyderabad Doctors successfully perform Asia's ...

Only 40 such surgeries reported around the world...
SuVitas Launches Bangalore’s First Dedicated Transition Care Facility

SuVitas Launches Bangalore’s First Dedicated ...

Catering to a need for post critical care that has...
Itermittent Fasting: The How s and Why's

Itermittent Fasting: The How s and Why's

Intermittent Fasting is the latest global fitness ...
Our responsibility to our emotions

Our responsibility to our emotions

In this world, there are all kinds of people. Some...
Stop drowsing while driving

Stop drowsing while driving

A long spell of work or drive can lead to physical...
Eyes show you the world

Eyes show you the world

With increasing rate of air pollution, the ways it...